is the pain modulatory action of 17β-estradiol in locus coeruleus of male rats is mediated by gabaa receptors?
نویسندگان
چکیده
introduction: estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (lc). estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and gabaa receptors. lc is involved in noradrenergic descending pain modulation. methods: in order to study the effect of 17β-estradiol on both acute and persistent pain modulation and its mechanisms, formalin was injected into the hind paw of male rats. formalin-induced responses including licking and flexing duration and paw jerking frequency were recorded for 60 min after injection of 50 μl of 2% formalin. also, the expression of α2 and γ1 subunits of gabaa receptor genes were examined by rt-pcr technique. results: the results of the current study showed that intra-locus coeruleus injection of 17β-estradiol attenuated the second phase, but not the acute phase of formalin induced pain (p< 0.05). gabaa receptor antagonist (bicuculline) reversed the antinociceptive effect of 17β-estradiol, but the expression level of α2 and γ1 subunits of gabaa receptor genes were not significantly changed. conclusion: it may be concluded that the analgesic effect of 17β-estradiol in formalin induced inflammatory pain is possibly mediated through the interaction with membrane-bound gabaa receptors, however this effect is not exerted at the gene expression level.
منابع مشابه
Is the pain modulatory action of 17β-estradiol in locus coeruleus of male rats is mediated by GABAA receptors?
Introduction: Estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (LC). Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and GABAA receptors. LC is involved in noradrenergic descending pain modulation. Methods: In order to study the effect of 17β-estra...
متن کاملIs the pain modulatory action of 17β-estradiol in locus coeruleus of male rats is mediated by GABAA receptors?
Introduction: Estradiol is a neuroactive steroid, which is found in several brain areas such as locus coeruleus (LC). Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membranebound receptors like glutamate and GABAA receptors. LC is involved in noradrenergic descending pain modulation. Methods: In order to study the effect of 17β-estradio...
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Introduction: 17β-Estradiol is a neuroactive steroid and its pain modulatory role has been well studied previously. 17β-Estradiol modulates nociception by binding to its receptors and also by allosteric interaction with other membrane - bound receptors such as glutamate and GABAA receptors. Paragigantocellularis lateralis (LPGi) is also involved in pain modulation and perception, in addition...
متن کاملAnalgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors
Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as wel...
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15 صفحه اولAnalgesic Effect of 17β-Estradiol on Nucleus Paragigantocellularis Lateralis of Male Rats Mediated Via GABAA Receptors
INTRODUCTION Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending pain modulation. 17β-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17β-estradiol can elicit the analgesic responses. 17β-Estradiol modulates nociception by binding to estrogenic receptors as well as allosteric ...
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عنوان ژورنال:
physiology and pharmacologyجلد ۱۴، شماره ۳، صفحات ۲۵۲-۲۶۱
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